Blt Mouse

Although blt humanized mice provide a robust model for hiv 1 infection and enable evaluation of cure strategies dependent on endogenous immune responses most mice develop graft versus host disease gvhd limiting their utility for extended hiv cure studies. Although bone marrow liver thymus blt humanized mice provide a robust model for hiv 1 infection and enable evaluation of cure strategies dependent on endogenous immune responses most mice develop graft versus host disease gvhd limiting their utility for extended hiv cure studies. The blt mouse model offers high engraftment efficacy development of human hematopoietic.
blt mouse blt mouse model

The blt model is created via surgical transplantation of human fetal liver and thymus under the mouse kidney capsule accompanied with intravenous injection of autologous fetal liver hematopoietic stem cells hscs derived from the same fetal liver donor.

Blt mouse. This new type of laboratory mouse a chimera called bone marrow liver thymic mice blt mice created by researchers at ut southwestern and university of. The blt mouse is a modification of the scid hu model which was developed by joseph mccune in the early 1900s. We are not talking about a rodent sandwich.